Albert Louis Anna Willemsens;Alex Herman Copmans;Jérôme Albert Joseph Hoet;Wouter Louis J Couck;Joannes Petrus Van Dun
发明人:
Alex Herman Copmans,Jérôme Albert Joseph Hoet,Albert Louis Anna Willemsens,Wouter Louis J Couck,Joannes Petrus Van Dun
申请号：
US13322575
公开号：
US08461341B2
申请日:
2010.05.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4′-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
