COPMANS ALEX HERMAN,COPMANS Alex Herman,HOET JEROME ALBERT JOSEPH,HOET Jerome Albert Joseph,WILLEMSENS ALBERT LOUIS ANNA,WILLEMSENS Albert Louis Anna,COUCK WOUTER LOUIS J.,COUCK Wouter Louis J.,VAN DU
申请号：
SI201030201
公开号：
SI2435406T1
申请日:
2010.05.27
申请国别(地区):
SI
年份:
2013
代理人:
摘要：
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
