COPMANS, ALEX HERMAN,HOET, JEROME ALBERT JOSEPH,WILLEMSENS, ALBERT LOUIS ANNA,COUCK, WOUTER LOUIS J.,VAN DUN, JOANNES PETRUS
申请号:
DK10724047
公开号:
DK2435406T3
申请日:
2010.05.27
申请国别(地区):
DK
年份:
2013
代理人:
摘要:
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.