Schryvers, Anthony B.,Moraes, Trevor F.,Gray-Owen, Scott
申请号：
EP14866832
公开号：
EP3077512A4
申请日:
2014.12.01
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.
