Anthony B. Schryvers,Trevor F. Moraes,Scott Gray-Owen
申请号：
US15100867
公开号：
US10149900B2
申请日:
2014.12.01
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.
