Schryvers, Anthony B.,Moraes, Trevor F.,Gray-Owen, Scott
申请号：
NZ72112114
公开号：
NZ721121A
申请日:
2014.12.01
申请国别(地区):
NZ
年份:
2020
代理人:
摘要：
The disclosure provides immunogenic compositions comprising a Transferrin binding protein B (TbpB) protein obtainable from or obtained from a Gram-negative bacterial species comprising a C-lobe domain or an N-lobe domain. The TbpB proteins have been modified in at least one loop domain in such a manner that they have reduced binding to transferrin. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.
