SCHRYVERS, ANTHONY B.,MORAES, TREVOR F.,GRAY-OWEN, SCOTT
申请号：
CA2931685
公开号：
CA2931685A1
申请日:
2014.12.01
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The disclosure provides immunogenic compositions comprising a polypeptide comprising a C-lobe domain or an N-lobe domain of a HIBP surface receptor protein obtainable from or obtained from a Gram-negative bacterial species. The HIBP surface receptor proteins have been modified in such a manner that they are unable to bind host iron binding protein. Methods of making and using these immunogenic positions to prepare animal and human vaccines are also provided.
