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N-(heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and use thereof
专利权人:
SANOFI-AVENTIS
发明人:
DUBOIS, LAURENT,MALANDA, ANDRE,EVANNO, YANNICK
申请号:
AU2006271524
公开号:
AU2006271524B2
申请日:
2006.07.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention concerns compounds of general formula (I) wherein: X, X, X, X represent, independently of one another, a hydrogen or halogen atom or a C-C-alkyl, C-C-cycloalkyl, C-C-cycloalkyl-C-C-alkylene, C-C-fluoroalkyl, C-C-alkoxyl, C-C-fluoroalkoxyl, cyano, C(O)NRR, nitro, NRR, C-C-thioalkyl, -S(O)-C-C-alkyl, -S(O)-C-C-alkyl, SONRR, NRCOR, NRSOR or aryl group, the aryl being optionally substituted; W represents a fused bicyclic group of formula (II) bound to the nitrogen atom by positions 1, 2, 3 or 4; A represents a five- or seven-membered heterocycle comprising from one to three heteroatoms selected among O, S or N; the carbon atom(s) of A being optionally substituted; n is equal to 1, 2 or 3; Y represents an optionally substituted heteroaryl; in base or acid addition salt form, as well as in hydrate or solvate form. The invention also concerns a method for preparing said compounds and their therapeutic use.
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