Kim, Yong Zu,Oh, Yeong Soo,Chae, Jeiwook,Song, Ho Young,Chung, Chul-woong,Park, Yun Hee,Choi, Hyo Jung,Park, Kyung Eun,Kim, Hyoungrae,Kim, Jinyeong,Min, Ji Young,Kim, Sung Min,Lee, Byung Soo,Woo, Dong
申请号：
AU2016359230
公开号：
AU2016359230A1
申请日:
2016.11.23
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody； a linker； and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent； and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
