KIM, YONG ZU,OH, YEONG SOO,CHAE, JEIWOOK,SONG, HO YOUNG,CHUNG, CHUL-WOONG,PARK, YUN HEE,CHOI, HYO JUNG,PARK, KYUNG EUN,KIM, HYOUNGRAE,KIM, JINYEONG,MIN, JI YOUNG,KIM, SUNG MIN,LEE, BYUNG SOO,WOO, DONG
申请号：
CA3006242
公开号：
CA3006242A1
申请日:
2016.11.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
In some aspects, the inventionrelates to an antibody-drug conjugate,comprising an antibody； a linker； and anactive agent. The antibody-drug conjugatemay comprise a self- immolative group.The linker may comprise an O-substitutedoxime, e.g., wherein the oxygen atom ofthe oxime is substituted with a group thatcovalently links the oxime to the activeagent； and the carbon atom of the oxime issubstituted with a group that covalentlylinks the oxime to the antibody.
