KIM YONG ZU,OH YEONG SOO,CHAE JEIWOOK,SONG HO YOUNG,CHUNG CHUL WOONG,PARK YUN HEE,CHOI HYO JUNG,PARK KYUNG EUN,KIM HYOUNGRAE,KIM JINYEONG,MIN JI YOUNG,KIM SUNG MIN,LEE BYUNG SOO,WOO DONG HYUN,JUN JI E
申请号：
IN201827022626
公开号：
IN201827022626A
申请日:
2018.06.18
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
In some aspects the invention relates to an antibody-drug conjugate comprising an antibody a linker and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime e.g. wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
