Yong Zu Kim,Yeong Soo Oh,Jeiwook Chae,Ho Young Song,Chul-Woong Chung,Yun Hee Park,Hyo Jung Choi,Kyung Eun Park,Hyoungrae Kim,Jinyeong Kim,Ji Young Min,Sung Min Kim,Byung Soo Lee,Dong Hyun Woo,Ji Eun J
申请号：
US15779446
公开号：
US20200297865A1
申请日:
2016.11.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody； a linker； and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent； and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
