Yong Zu Kim,Yun Hee Park,Hyo Jung Choi,Ji Eun Jung,Jeong Hee Ryu,Ho Young Song,Jeiwook Chae,Chul-Woong Chung
申请号：
US15276231
公开号：
US10118965B2
申请日:
2016.09.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody a linker and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
