The present invention provides the compound of a kind of prevention that can be used as sex hormone-dependent disease etc. or therapeutic agent. The present invention provides a kind of nitrogenous condensed ring derivatives represented with the following general formula (I), premedicant, salt etc. with GnRH antagonism, and the medical component containing it and its medical usage etc.. In formula (I), ring A and ring B stand alone as aryl or heteroaryl； RAAnd RBStand alone as halogen, cyano, alkyl, Alkylsulfonyl ,-OW1,-SW1,-COW2,-NW3W4,-SO2NW3W4, aryl etc.； RCFor H or alkyl； E is oxygen atom etc.； U is singly-bound or stretches alkyl； X is Y ,-CO-Y ,-SO2- Y ,-S- (stretching alkyl)-Y ,-O- (stretching alkyl)-Y ,-SO2(Y is Z or amido etc. to (stretching alkyl)-Y etc.； Z is naphthenic base, Heterocyclylalkyl, aryl, heteroaryl etc.) etc..本發明提供一種可用作性激素依賴性疾病等的預防或治療劑之化合物。本發明提供一種具有GnRH拮抗作用之以下述通式(I)所表示之含氮縮合環衍生物、前驅藥、鹽等，以及含有其之醫藥組成物及其醫藥用途等。式(I)中，環A及環B獨立為芳基或雜芳基；RA及RB獨立為鹵素、氰基、烷基、烷基磺醯基、－OW1、－SW1、－COW2、－NW3W4、－SO2NW3W4、芳基等；RC為H或烷基；E為氧原子等；U為單鍵或伸烷基；X為Y、－CO－Y、－SO2－Y、－S－(伸烷基)－Y、－O－(伸烷基)－Y、－SO2－(伸烷基)－Y等(Y為Z或胺基等；Z為環烷基、雜環烷基、芳基、雜芳基等)等。
