The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl； R A represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like； ring B represents aryl or heteroaryl； R B represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like； E 1 and E 2 represent an oxygen atom or the like； U represents a single bond or alkylene； X represents a group represented by Y, -SO 2 -Y, -O-(alkylene)-Y, -O-Z in which Y represents Z, amino or the like； Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like； or the like.本發明係提供可用於作為性荷爾蒙依存性疾病等之預防或治療劑的化合物。亦即，提供依下述一般式(I)所示之縮合雜環衍生物、含有其之醫藥組成物及其之醫藥用途等。式(I)中，環A為5員環不飽和烴或5員環雜芳基；RA為鹵素、烷基、烯基、炔基、羧基、烷氧基、胺甲醯基、烷基胺甲醯基等；環B為芳基或雜芳基；RB為鹵素、烷基、羧基、烷氧基、胺甲醯基、烷基胺甲醯基等；E1、E2為氧原子等；U為單鍵或伸烷基；X為Y、－SO2－Y、－O－(伸烷基)－Y或－O－Z所示之基(Y為Z或胺基等；Z為環烷基、雜環烷基、芳基、雜芳基等)；等。
