GATTI MCARTHUR, SILVIA,GOETSCHI, ERWIN,WICHMANN, JUERGEN,WOLTERING, THOMAS JOHANNES
申请号：
ES07727038
公开号：
ES2529457T3
申请日:
2007.03.19
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** which is in which the 5 or 6 membered heteroaryl is imidazolyl, [1,2,4] oxadiazolyl, pyrrolyl, 1H-pyrazolyl, pyridinyl, [1,2, 4] triazolyl, thiazolyl, pyrimidinyl or thiophenyl, each of which optionally substituted with C1-6 alkyl； B is an optionally substituted aryl or an optionally substituted 5 or 6 membered heteroaryl, wherein the substituents are selected from the group consisting of: halo, nitro, C1-6 alkyl optionally substituted with hydroxy, NRaRb, in which Ra and Rb are independently H, C1-6 alkyl or - (CO) -C1-6 alkyl, -S-C1-6 alkyl, - (SO2) -OH, - (SO2) -C1-6 alkyl, - (SO2) -NRcRd, in which Rc and Rd are independently: H, C1-6 alkyl optionally substituted with hydroxy, C1-6 haloalkyl, C1-6 alkoxy, - (CO) C1-6 alkyl optionally substituted with C1-6 alkoxy, - (CH2CH2O) nCHRe, where Re is H or CH2OH and n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10, - (CH2) m-aryl, where m is 1 or 2 and the aryl is optionally substituted with halo or C1-6 alkoxy, - (CH2) p3-6 cycloalkyl, wherein p is 0 or 1, 5 or 6 membered heteroalkyl, - (SO2) -NRfRg, in which Rf and Rg together with the nitrogen atom to which they are attached form a 4, 5 or 6-membered heterocycloalkyl ring containing op an additional heteroatom selected from nitrogen, oxygen, sulfur or an SO2 group, wherein said 4, 5 or 6 membered heterocycloalkyl ring is optionally substituted with: a substituent selected from the group consisting of hydroxy, C1-6 alkyl, C1-6 alkoxy which is optionally substituted with hydroxy, and a 5- or 6-membered heteroaryloxy, NHSO2-C1-6 alkyl, and NHSO2-NRhRi in which Rh and Ri are independently H, C1-6 alkyl, - (CO) O- C1-6 alkyl, or Rh and Ri together with the nitrogen atom to which they are attached form a 4, 5 or 6 membered heterocycloalkyl ring optionally containing an additional heteroatom selected from nitrogen, oxygen or sulfur, wherein said 4, 5 or 6-membered heterocycloalkyl ring is optionally substituted with C1-6 alkyl； R1 is H, halogen,
