Bong-Sik Jeon,Eung Gyu Kim,Eun Byul Kwon,Ju Young Park,Wan Jae Myeong
申请号：
US13819525
公开号：
US20130164223A1
申请日:
2011.08.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided.5≦100*Dμ(IO)/Cω(IO) [Relation 1]2.5≦100*Dμ(Cap)/Cω(Cap) [Relation 2]0.5 wt %≦F(IO)≦50 wt % [Relation 3]1 nm≦Dμ(IO)≦25 nm [Relation 4]50 nm≦Dμ(Cap)≦200 nm [Relation 5]
