RODGERS JAMES D.,SHEPARD STACEY,ZHU WENYU,SHAO LIXIN,GLENN JOSEPH
申请号：
ARP110104324
公开号：
AR083933A1
申请日:
2011.11.18
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
1. Regulating the ingredients and methods of use of Anu kunbasas activities can help to treat diseases related to Jacques kunbasas activities, including inflammation, autoimmune disorders, cancer and other diseases.Or a salt acceptable for a drug, wherein: X is ch or N； y is h, cyanogen, halogen, c1-3 tar or c1-3 halogen tar； Z is Cr4 or N； W is ch or N； W is ch, then l is O, s, C (R6) 2, C (= O),C (3DO) N (R7)C (3DO) O C (3DO) C (R6) 2 S (3DO)S (3DO) 2 S (O) N (R7)S (= O) 2n (R7) or C (= n7a) n (R7)；Or if W is n, then l is C (R6) 2, C (= O),C (3DO) O C (3DO) N (R7)C (3DO) C (R6) 2 S (3DO)S (3DO) 2 S (3DO) N (R7)S (= O) 2n (R7) or C (= n7a) n (R7)；R1, R2, R3 and R4 are independent h, hydroxy, halogen, c1-3 or c1-3 halides； each R5 is independent hydrogen Xi, C1-4 alkane, fluorine, C1-4 hydrocarbon, C1-4 hydrocarbon, C1-4 oxytoxine C1-4 or C1-4 fluorinated hydrocarbon； each R6 is independent h or C1-4； or C1-4 fluorinated hydrocarbon； or two groups of 6. They are combined with carbon atoms to form a cyclopentadiene tar of 3, 4, 5 or 6 members； R7 is h or C1-4 tar； r7a is h, oh, CN, alcox C1-4 or C1-4 tar； or R and r7a are combined with other C (= n) to form a non cyclopentadiene of 4, 5, The heteromorphic ring a of 6 or 7 members or 5 or 6 members is hc1-6C3-10 cycloalkyl, C2-10 heterocycloalkyl, C6-10 aryl or C1-10 heteroaryl； wherein said C1-6 alkyl, C3-10 cycloalkyl, C2-10 heterocycloalkyl, C6-10 aryl and C1-10 heteroaryl are each optionally substituted with independently selected R8 substituents； where p is 1, 2, 3, 4 or 5； provided that, when L is O, S, C (= O),C (= O) O, S (= O) or S (= O) 2, so A is not H； each R8 is independently selected from halo, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl , C2-10 heterocycloalkyl, C2-10 heterocycloalkyl-C1-4 alkyl, C6-10 aryl, C6-10 aryl-C1-4 alkyl, C1-10 heteroaryl, C1-10 heteroaryl-C1-4 alkyl, -ORa, - SRa, -S (= O) Rb, -S (= O) 2Rb, -S (= O) 2NReRf,
