FELDING, JAKOB,LIANG, XIFU,HORNEMAN, ANNE MARIE,POULSEN, TINA,LARSEN, JENS
申请号：
ES09776187
公开号：
ES2445517T3
申请日:
2009.08.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of general formula I in which: R1 represents hydrogen or a linear, saturated or unsaturated C1-2 hydrocarbon radical； R2 and R3 represent hydrogen or a linear or branched, saturated or unsaturated C1-6 hydrocarbon radical； D represents nitrogen or CH； E represents nitrogen or CH； G represents nitrogen or CH； J represents nitrogen or CH； L represents nitrogen or CH； n represents an integer from 1-2； W represents oxygen or sulfur； R4 represents hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-6 hydroxyalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C6-12 aryl, C3-12 heteroaryl or heterocycloalkenyl C2-7 wherein said C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-6 hydroxyalkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C6-12 aryl, C3-12 heteroaryl or C2-7 heterocycloalkenyl are optionally substituted with one or more equal or different substituents independently selected from the group consisting of hydrogen, halogen, oxo, hydroxyl, trifluoromethyl, carboxyl, cyano, C1-6 alkyl, C2-6 alkenyl, C1-6 alkoxy, C 1-6 alkoxycarbonyl, C 1-6 alkylthio, trifluoromethyl, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 2-7 heterocycloalkyl, C 2-7 heterocycloalkenyl, C 6-12 aryl, C 3-12 heteroaryl and C 1-3 alkylamino wherein said alkyl C1-6, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkylthio, trifluoromethyl, c C3-8 icloalkyl, C3-8 cycloalkenyl, C2-7 heterocycloalkyl, C2-7 heterocycloalkenyl, C6-12 aryl, C3-12 heteroaryl and C1-3 alkylamino are optionally substituted with one or more odifferent equal substituents independently selected from hydroxyl, alkyl C1-4, C1-4 alkyloxycarbonyl； or R3 and R4 together form part of a C3-8 cycloalkyl； Y represents carbonyl or thioxo； R 5 represents hydrogen, C 1-6 alkyl, C 1-6 alkylamino, C 1-6 alkoxy, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, C 2-7 heterocycloalkyl or C 2-7 heteroaryl, wherein said C 1-6 alkyl, C 1-6 alkylamino -6, C1-6 alkoxy, C3-8 cycloalkyl, C2-7 heterocycloalkyl or C2-7 het
