НОВЫЕ ПРОИЗВОДНЫЕ АЗОТСОДЕРЖАЩИХ НАСЫЩЕННЫХ КАРБОЦИКЛОВ В КАЧЕСТВЕ ИНГИБИТОРОВ МУСКАРИНОВЫХ РЕЦЕПТОРОВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ МУСКАРИНОВЫХ РЕЦЕПТОРОВ
Общество с ограниченной ответственностью "Асинэкс Медхим" (RU)
发明人:
Кочубей Валерий Сергеевич (RU)
申请号：
RU2011132796/04
公开号：
RU2011132796A
申请日:
2011.08.04
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A compound of the general formula (1) wherein fragmentvybran izgde X represents hydrogen, alkyl, SNA (O) - (CH) SNSNS (O) - (*) indicates the point of attachment to Het, R soboy- H - alkyl optionally substituted one or more times by a group selected from OH Oalkila COOH CONRR C-cycloalkyl optionally containing one heteroatom selected from nitrogen, and optionally substituted one or more times by OH, SOalkilom Sarila optionally substituted one or more times by halogen, CF, NNSOalkilom, Oalkilom optionally substituted 6-membered heteroaromatic group containing nitrogen as a heteroatom SOgeterotsikloalkil where heterocycloalkyl is a 5-7-membered saturated heterocyclic group containing one or two heteroatoms selected from nitrogen and oxygen 5-10 membered heteroaromatic group, containing one to three heteroatoms selected from nitrogen, oxygen and sulfur, which may be substituted one or more times with alkyl, -NRR, 5-6-membered saturated heterocyclic group containing one or two heteroatoms selected from nitrogen and oxygen, - C -Stsikloalkil optionally containing one heteroatom selected from nitrogen and oxygen, and optionally substituted once or several times SOalkilom - Saril optionally substituted one or more times by halogen, alkyl, Oalkilom - 5-6-membered heteroaromatic group containing one- two g eteroatoma selected from nitrogen, optionally substituted one or several times by alkyl - SOalkil optionally substituted one or more times by a group selected from NRR NNSOzalkila alkyl Oalkila S-cycloalkyl, optionally containing one or two heteroatoms oxygen and sulfur, which may be substituted one or more times with alkyl, -NRR, 5-6-membered saturated heterocyclic group containing one or two heteroatoms selected from nitrogen and oxygen, - C cycloalkyl optionally containing one heteroatom selected from nitrogen and oxygen, and optionally substituted once or several times SOalkilom - Saril optionally substituted one or more times by halogen, alkyl, Oalkilom - 5-6-membe
