RONGVED, Pål,ÅSTRAND, Ove Alexander Høgmoen,BAYER, Annette,LEIROS, Hanna-Kirsti Schrøder,SAMUELSEN, Ørjan,EDVARDSEN, Kine Susann Waade,MUHAMMAD, Zeeshan
申请号：
ES14789590
公开号：
ES2691536T3
申请日:
2014.10.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound for use in a method of treatment or prevention of bacterial infection in a human or non-human Mammal,Said method comprising the Administration of said compound in combination with (Well simultaneously, separately or sequentially) of a beta lactam antibiotic,The said Compound is a compound of formula I: * * * * formula: where a represents a rest that is selective for the Hydrophilic chelating Zn2 + ions from picoilamina and comprises two orMore units of 2-pyridyl Methyl in which: (a) and L is a link or a Linker and B is a Vector that is selected from (i) a structure comprising one or more of the following groups: L -L - alanine, Lysine, D - glutamic acid, l-glutamic acid, glutamine acid (D -, meso - diaminopimélico D - 2.3 - diamino acid, propanoic acid,D - alanine or any other amino acid that has the configuration d (ii) an antibacterial agent or a macrolide antibiotic and (iii) or (b) - L - B comprises the following structures (in QEU * indicates the point of Union of L to the rest): * * * * in the formula or the compound I is a compound of formula II: * * * * formula where p is an integer from 0 to 4, preferably 1, 2 or 3,For example, 1 or 2 each X is selected independently between c1-3 alkyl (e.g. Methyl alkoxy), C1 (e.g., methoxy - 3 - NO2), for example, halogen (F, CL,Haloalquilo C1 or BR) and 3 - (e.g. Cf3), or where two adjacent groups X, together with the Ring Atoms involved,Form a Heterocyclic Ring or carbocíclico optionally substituted (For example, a ring benzofuranilo or optionally substituted phenyl) or a pharmaceutically acceptable Salt of the same.Un compuesto para su uso en un método de tratamiento y/o prevención de una infección bacteriana en un ser humano o mamífero no humano, comprendiendo dicho método la administración de dicho compuesto en combinación con (bien simultáneamente, por separado o secuencialmente) de un antibiótico de ß-lactama, en el que dicho compuesto es un compuesto de Fórmula I:**Fórmula** en donde: A representa un re
