JAROSKOVA, LIBUSE,LINDERS, JOANNES THEODORUS MARIA,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,VAN DER VEKEN, LOUIS JOZEF ELISABETH
申请号：
CA2565632
公开号：
CA2565632C
申请日:
2005.04.29
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The N-oxide forms, the pharmaceutically acceptable addition salts and thestereochemically isomeric forms thereof, wherein n is 1 or 2； M represents adirect bond or a C1-3alkyl linker optionally substituted with one or twosubstituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl-, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl-； R1 and R2 eachindependently represent hydrogen, halo, cyano, hydroxy, Cl-4alkyl optionallysubstituted with halo, C1-4alkyloxy- optionally substituted with one or wherepossible two or three substituents selected from hydroxy, Ar1 and halo ； R3represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-, cyano or hydroxy； R4represents hydrogen, halo, Cl-4alkyl, hydroxy, cyano or C1-4alkyloxy-optionally substituted with one or where possible two or three substituentsselected from hydroxy and halo； R5 represents hydrogen, C1-4alkyl or Ar2-C1-4alkyl-； R6 represents hydrogen, hydroxy, halo, C1-4alkyl or C1-4alkyoxy-； R7represents hydrogen or R7 and R5 taken together with the carbon atom to whichthey are attached from a -C2-alkyl- linker； Ar1 and Ar2 each independentlyrepresent phenyl or naphtyl wherein said phenyl and naphtyl are optionallysubstituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl.
