JAROSKOVA, LIBUSE,LINDERS, JOANNES THEODORUS MARIA,BUYCK, CHRISTOPHE FRANCIS ROBERT NESTOR,VAN DER VEKEN, LOUIS JOZEF ELISABETH,DIMITROV, VLADIMIR DIMTCHEV,NIKIFOROV, THEO TEOFANOV
申请号：
CA2565630
公开号：
CA2565630C
申请日:
2005.04.29
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Formula (I), the N-oxide forms, the pharmaceutically acceptable addition saltsand the stereochemically isomeric forms thereof, wherein n is 1 or 2； Lrepresents a C1-3alkyl linker optionally substituted with one or twosubstituents selected from C1-4alkyl, C1-3alkyloxy-C1-4alkyl-, hydroxy-C1-4alkyl, hydroxy, C1-3alkyloxy- or phenyl-C1-4alkyl； M represents a direct bondor a C1-3alkyl linker optionally substituted with one or two substituentsselected from hydroxy, C1-4alkyl or C1-4alkyloxy； R1 and R2 each independentlyrepresent hydrogen, halo, cyano, hydroxy, C1-4alkyl optionally substitutedwith halo, C1-4alkyloxy- optionally substituted with one or where possible twoor three substituents selected from hydroxy, Ar1 and halo； or R1 and R2 takentogether with the phenyl ring to which they are attached form naphtyl or 1,3-benzodioxolyl, wherein said naphtyl or 1,3-benzodioxolyl are optionallysubstituted with halo； R3 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-,cyano or hydroxy； R4 represents hydrogen, halo, C1-4alkyl, C1-4alkyloxy-,cyano or hydroxy； R5 represents hydrogen, C1-4alkyl or Ar2-C1-4alky-； R6represents hydrogen, halo, C1-4alkyl Or C1-4alkyoxy-； Ar1 and Ar2 eachindependently represent phenyl or naphtyl wherein said phenyl and naphtyl areoptionally substituted with C1-4alkyl, C1-4alkyloxy-, or phenyl-C1-4alkyl； foruse as a medicine.
