CLAIBORNE, CHRISTOPHER F.,SELLS, TODD B.,STROUD, STEPHEN G.
申请号：
ES12153131
公开号：
ES2528793T3
申请日:
2007.11.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): Formula ** ** or a pharmaceutically acceptable salt thereof, wherein: Ra is selected from the group consisting of C1-3 aliphatic, C1-3 fluoroaliphatic, -R 1, -T R1, R2 and -T-R2 T is a C1-3 alkylene chain optionally substituted with fluoro R1 is optionally substituted with one or two substituents independently selected from the group consisting of halo, C1-3 aliphatic, and C1-3 fluoroaliphatic aryl, heteroaryl or 5- or 6-membered R2 is selected from the group consisting of halo, -C≡C-R 3, -CH> = CH-R3, -N (R4) 2 and -OR 5 R3 is hydrogen, C1-3 aliphatic, or C1-3 fluoroaliphatic -CH2OCH3 heterocyclyl or aryl group, or heteroaryl each R4 independently is hydrogen or an aliphatic, aryl, heteroaryl or heterocyclyl or two R4 on the same nitrogen atom, taken together with the nitrogen atom form a heteroaryl ring or 5 to 6 membered heterocyclyl 4 to 8 membered, besides the nitrogen atom, having 0-2 ring heteroatoms selected from N, O and S R5 is hydrogen, C1-3 aliphatic, C1-3 fluoroaliphatic, or a heterocyclyl aryl, heteroaryl or and Rb is selected from the group consisting of fluorine, chlorine, -CH3, -CF3, -OH, -OCH3, -OCF3, -OCH2CH3 and - OCH2CF3 for use in treating a proliferative disorder.Un compuesto de fórmula (I):**Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: Ra se selecciona entre el grupo que consiste en alifático C1-3, fluoroalifático C1-3, -R1, -T-R1,-R2 y -T-R2 T es una cadena alquileno C1-3 opcionalmente sustituida con flúor R1 es un anillo arilo, heteroarilo o heterociclilo de 5 ó 6 miembros opcionalmente sustituido con uno o dos sustituyentes seleccionados independientemente entre el grupo que consiste en halo, alifático C1-3 y fluoroalifático C1-3 R2 se selecciona entre el grupo que consiste en halo, -C&equivC-R3, -CH>=CH-R3, -N(R4)2 y -OR5 R3 es hidrógeno, alifático C1-3, fluoroalifático C1-3 o -CH2OCH3 o un grupo arilo, heteroarilo o heterociclilo cada R4 independientemente es hidrógeno o un grupo alifát
