RONGVED, Pål,ÅSTRAND, Ove Alexander Høgmoen,BAYER, Annette,LEIROS, Hanna-Kirsti Schrøder,SAMUELSEN, Ørjan,EDVARDSEN, Kine Susann Waade,MUHAMMAD, Zeeshan
申请号：
EP14789590
公开号：
EP3052135B1
申请日:
2014.10.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Compounds according to formula I are provided: A-L-B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ions L is a covalent bond or a linker and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-β-lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. A method of treating and/or preventing a bacterial infection in a human or non-human mammal employing such compounds are also provided. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a β-lactam antibiotic.
