RONGVED, PAL,ASTRAND, OVE ALEXANDER HOGMOEN,BAYER, ANNETTE,LEIROS, HANNA-KIRSTI SCHRODER,SAMUELSEN, ORJAN,EDVARDSEN, KINE SUSANN WAADE,MUHAMMAD, ZEESHAN
申请号：
CA2926156
公开号：
CA2926156A1
申请日:
2014.10.06
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention provides compounds according to formula I: A - L - B wherein A represents a lipophilic chelating moiety which is selective for Zn2+ ions L is a covalent bond or a linker and B is a vector which is either a moiety capable of interacting with one or more biological structures found in a bacterium (preferably in a bacterial cell wall), for example a penicillin-binding protein such as a metallo-ß- lactamase or DD-transferase, or a moiety capable of enhancing transport of the compound across a bacterial cell membrane. Such compounds find use in a method of treating and/or preventing a bacterial infection in a human or non-human mammal. In such a method, the compound of formula I may be administered in combination with (either simultaneously, separately, or sequentially) a ß-lactam antibiotic.
