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new compounds
- 专利权人:
- Proximagen Limited
- 发明人:
- PATIENT, Lee,EVANS, David,SIMPSON, Iain,POWELL, Allison
- 申请号：
- ES14711577
- 公开号：
- ES2663448T3
- 申请日:
- 2014.03.13
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- A compound of formula (I) or a pharmaceutically acceptable salt or an N-oxide thereof: ** (See formula) ** wherein Y is selected from hydrogen, hydroxyl, -NH2, -NH-(C1-4) alkyl , -NH-halo (C1-4) alkyl or C1-4 alkoxy； Z is selected from hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, halo (C1-4) alkyl, C1-4 alkoxy, halo (C1-4) alkoxy, CONH2, SO2NH2, -NH2, -NH- (C1-4) alkyl, -NH-halo (C1-4) alkyl； R1 is a phenyl ring, or a 5- or 6-membered heteroaryl ring, each ring being optionally substituted with one or more substituents selected from halogen, cyano, C1-4 alkyl, halo (C1-4) alkyl, cyanoalkyl ( C1-4), C1-4 alkoxy, halo (C1-4) alkoxy, -NR4AR4B, -NR6C (O) OR5, -NR6C (O) R5, -NR6C (O) NR4AR4B, - 10 C (O) NR4AR4B , -C (O) R5, -C (O) OR5 and -NR6S (O) 2R5； W is a phenyl ring or a 5- or 6-membered heteroaryl ring, each ring being optionally substituted with one or more substituents selected from halogen, cyano, C1-4 alkyl, halo-C1-4 alkyl, cyano-C1 alkyl -4), C1-4 alkoxy, halo (C1-4) alkoxy, -NR4AR4B, -NR6C (O) OR5, -NR6C (O) R5, -NR6C (O) NR4AR4B, - C (O) NR4AR4B, - C (O) R5, -C (O) OR5, -SO2R5, -SO2NR4AR4B and -NR6S (O) 2R5； R2 is -B-Q- [R3] n or -B-R3； wherein n>； = 1, 2, 3 or 4 B is a bond, -O-, -NR5-, -C (O) - or C1-3 alkylene； Q is a 3-7 membered heterocyclic ring or C3-7 saturated or partially unsaturated cycloalkyl； when R2 is -BO- [R3] n, R3 is selected from hydrogen, halogen, cyano, amino, hydroxyl, oxo, C1-4 alkyl, halo (C1-4) alkyl, C1-4 alkoxy, (C1-) alkoxy 4) -C 1-4 alkyl, hydroxy-C 1-4 alkyl, cyano-C 1-4 alkyl, aminoC 1-4 alkyl, C 1-4 alkyl-amino-C 1-4 alkyl 4), di (C1-4 alkyl) - amino (C1-4) alkyl, -NR4AR4B, -NR6C (O) OR5, - NR6C (O) R5, -NR6C (O) NR4AR4B, -C (O ) NR4AR4B, -C (O) R5, -C (O) OR5, -NR6S (O) 2R5, -S (O) 2R5, alkyl (C1-4) - NR6C (O) OR5, -alkyl (C1-4) ) -NR6C (O) NR4AR4B, amino (C1-4) alkoxy-(C1-4) alkyl -, (amino (C1-4) alkyl) - amino (C1-4) alkyl -, - (C1-alkyl) -4) -C (O) R5, -OC (O) R5, -alkyl (C1-4) -C (O) OR5, -alkyl (C1-4) -C (O) NR4AR
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
