ПРОИЗВОДНЫЕ ИНДОЛИН-2-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ

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专利权人:

АННЦЗИ ФАРМАСЬЮТИКАЛ КО.; ЛТД. (TW)

发明人:

ЧЭРН Цзи-Ван (TW),ДЖАГТАП Ацзит Дхананьджей (TW),ВАНЬ Хсыао-Чунь (TW),ЧЭНЬ Грейс Шиаху (TW)

申请号：

RU2014145480

公开号：

RU2014145480A

申请日:

2013.04.03

申请国别(地区):

RU

年份:

2016

代理人:

摘要：

1. A compound of formula A: or a pharmaceutically acceptable salt, solvate or hydrate thereof, a prodrug or metabolite, (I) wherein: R4 is hydrogen, (C1-C4) aryl, halo (C1-C4) aryl or (C1-C4) alkoxy (C-C) aryl R <3> is hydrogen, (C-C) heteroaryl, (C-C) alkoxy (C-C) heteroaryl (C-C) alkyl (C-C) heteroaryl, (C-C) alkyl (C-C) alkoxy (C-C) heteroaryl, (C-C) alkyl (C-C) carboxyalkyl (C-C) heteroaryl (C1-C4) alkyl ((C1-C4) -alkylamino (C1-C4) alkylcarbamoyl) (C1-C4) heteroaryl (C1-C4) alkyl (C1-C4) aryl (C1-C4) heteroaryl, (C1-C2C6) alkyl (C1-C2C6) alkoxycarbonyl (C1-C4) heteroaryl, (C1-C2C6) (C-C) oxyalkyl (C-C) heteroaryl, (C-C) alkyl (C-C) heterocyclylcarbonyl (C-C) heteroaryl, (C-C) alkyl (C-C) heterocyclyl (C-C) oxyalkyl (C-C) heteroaryl or (C-C) alkyl (C-C) heterocyclyl (C-C) alkylcarbamoyl) (C-C) heteroaryl R3 is hydrogen, (C1-C4) alkoxybenzoylureido or halo ) aryl (C-C) heteroarylamido R4 is hydrogen, halogen, (C1-C4) alkoxybenzoylureido or halo (C1-C4) aryl (C1-C4) heteroarylamido R3 is benzoylureido, halobenzoylureido, halo (C1-C4) alkoxybenzoylureido, (C1-C4) alkoxybenzoylureido, -C) alkylaminobenzoylureido, (C-C) alkylbenzoylureido, nitrobenzoylureido, (C-C) haloalkylbenzoylureido, (C-C) haloalkyl halobenzoylureido, halo (C-C) arylcarbomylacetamido, (C-C) alkoxy (C-C) arylcarbomylacetamido, ( C-C) alkoxy (C-C) arylcarbamoyl (C-C) cycloalkylamido, halo (C-C) aryl (C-C) heteroarylcarbonylamino, (C-C) cycloalkyl (C-C) heteroaryl (C-C) -alkylamino (C-C) aryl (C-C) heteroarylcarbonylamino, halo (C-C) alkoxy (C-C) aryl (C-C) heteroarylcarbonylamino, (C-C) alkoxy (C- C) aryl (C-C) heteroarylcarbonylamino, (C-C) alkyl (C-C) heteroarylcarbonylamino, aryl (C-C) heteroarylcarbonylamino, (C-C) haloalkylgalo (C-C) aryl (C-C) heterocyclylcarbonylamino,

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