A compound of formula (II)a divalent benzene residue which is unsubstituted or substituted by one or two additional substituents independently selected from lower alkyl halo-lower alkyl hydroxy-lower alkyl lower alkoxy-lower alkyl acyloxy-lower alkyl phenyl hydroxy lower alkoxy hydroxy-lower alkoxy lower alkoxy-lower alkoxy phenyl-lower alkoxy lower alkylcarbonyloxy amino mono(lower alkyl)amino di(lower alkyl)amino mono(lower alkenyl)amino di(lower alkenyl)amino lower alkoxycarbonylamino lower alkylcarbonylamino substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl lower alkylcarbonyl carboxy lower alkoxycarbonyl cyano halogen and nitro or wherein two adjacent substituents can be methylenedioxy or a divalent pyridine residue (Z = N) which is unsubstituted or substituted additionally by lower alkyl lower alkoxy lower alkoxy-lower alkoxy amino optionally substituted by one or two substituents selected from lower alkyl lower alkenyl and alkylcarbonyl halo-lower alkyl lower alkoxy-lower alkyl or halogen R1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl and R2 represents a group selected from:or pharmaceutically acceptable salts thereof.
