Use of substituted 10-(3-piperazin-1-yl-propyl)-10H-phenothiazine-2-thiol compounds (I) for treating neurodegenerative diseases, is claimed. Use of substituted 10-(3-piperazin-1-yl-propyl)-10H-phenothiazine-2-thiol compounds of formula (I) for treating neurodegenerative diseases, is claimed. R1, R2 : 1-6C-alkyl (optionally substituted by alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio or halo)； R3 : H, alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio, halo, NR4R5- or OR6； R4-R6 : H or 1-3C-alkyl； R7 : H, alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio, halo, NR8R9 or OR10； and R8-R10 : H or 1-3C-alkyl. [Image] ACTIVITY : Neuroprotective； Nootropic； Anticonvulsant； Antiparkinsonian； Cerebroprotective； Hypnotic； Antiinflammatory. MECHANISM OF ACTION : None given.
