ДОМИНГЕЗ Селия,ТОЛЕДО-ШЕРМАН Летиция М.,ВИНКЛЕР Дирк,БРУКФИЛД Фредерик,ДЕ АГУИАР ПЕНА Паула С.
申请号：
RU2012133475
公开号：
RU2012133475A
申请日:
2011.01.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound selected from compounds of Formula I and its pharmaceutically acceptable salts and prodrugs, wherein: R is selected from optionally substituted aryl and optionally substituted heteroaryl R is selected from cyano, optionally substituted heteroaryl and optionally substituted heterocycloalkyl R is selected from hydrogen and optionally substituted lower alkyl and R is selected from hydrogen, halogen and optionally substituted lower alkyl. A compound according to claim 1, wherein R 1 is phenyl optionally substituted with one, two or three groups selected from halo, optionally substituted lower alkyl, optionally substituted lower alkoxy and hydroxy. A compound according to claim 2, wherein R 1 is phenyl optionally substituted with one, two or three groups selected from halo, lower alkyl, trifluoromethyl, trifluoromethoxy, lower alkoxy and hydroxy. A compound according to claim 3, wherein R 1 is phenyl optionally substituted with one, two or three groups selected from halo, lower alkyl, trifluoromethoxy and trifluoromethyl. The compound of claim 4, wherein R is selected from the following: 3-chloro-4-trifluoromethoxyphenyl, 3-chloro-4-methylphenyl, 3-fluoro-4-methylphenyl, 3-chloro-4-fluorophenyl, 3-chloro-4-isopropoxyphenyl , 3,4-difluorophenyl, 2-trifluoromethylphenyl, 3,4-dichlorophenyl, 3-chlorophenyl, 4-chlorophenyl and 3,5-dichlorophenyl. A compound according to claim 1, wherein R3 is pyridin-3-yl optionally substituted with one, two or three groups selected from halo, lower alkyl, lower alkoxy, optionally substituted amino, optionally substituted heterocycloalkyl, optionally substituted heteroaryl and hydroxy. A compound according to claim 6, wherein R3 is pyridin-3-yl optionally substituted with one, two or three groups selected from optionally substituted with one, two or three groups selected from halo, lower alkyl, trifluoromethoxy and trifluoromethyl. The compound of claim 4, wherein R is selected from the following: 3-chloro-4-trifluoromethoxyphe
