ПЕРО Джозеф Е. (US),ЛЕМАН Ханна Д. Дж. Ф. (US),ЛЕЙТОН Марк Э. (US),РОССИ Майкл А. (US),КЕЛЛИ Майкл Дж. III (US)
申请号：
RU2015119640
公开号：
RU2015119640A
申请日:
2013.10.23
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound or a pharmaceutically acceptable salt thereof having the structural formula Aili Formula A: Formula A, Formula A, wherein: "Het" is a heteroaryl radical containing from 5 to 7 ring atoms and 1 to 3 heteroatoms which are independently for each occurrence sulfur or nitrogen and which may be optionally substituted with alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenilom, heteroaralkyl, alkilgeteroarilom, geteroaralkenilom, hydroxy, hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, Additional physical layer but, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, alkylsulfonyl, arylsulfonyl, geteroarilsulfonilom, alkylsulfinyl, arilsulfinilom, geteroarilsulfinilom, alkylthio, arylthio, heteroarylthio, aralkylthio, geteroaralkiltio, cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, RRN-, RRN-alkilom-, RRNC ( O) - and RRNSO-, wherein each of R Ryavlyaetsya independently: hydrogen, alkyl, aryl and aralkyl one of the "R" or "R" is -H, and the other is independently: -H Calkilom halogen Ryavlyaetsya -H or Calkilom which is optionally substituted: Calkilom halogen -alkoxy -OH -CN alkylthio amino, -NH (linear or branched alkyl), -NH (cycloalkyl), -N (alkyl), - (C = O) -OH -C (O) O-alkyl -S (alkyl) or -S (O) -alkyl or -aryl cycloalkyl, each optional substituent may itself be substituted: alkyl, aryl, heteroaryl, aralkyl, alkylaryl, aralkenilom, heteroaralkyl, alkilgeteroarilom, geteroaralkenilom, hydroxy (also referred to as "hydroxyl" at a single location as a substitute residue), hydroxyalkyl, alkoxy, aryloxy, aralkoxy, acyl, aroyl, halo, nitro, cyano, carboxy, alkoxycarbonyl,
