WALL, Mark,SUBASINGHE, Nalin,SUI, Zhihua,FLORES, Christopher
申请号：
ES13753391
公开号：
ES2600743T3
申请日:
2013.08.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I) ** Formula ** in which X1, X2, X3 and X4 are independently CH or N； n is 0, 1 or 2； R1 is selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, di (C1-4 alkyl) amino, C1-4 alkyl amino, amino, pyrrolidin-1-yl, nitro, halo, trifluoromethoxy, trifluoromethyl, and cyano； R2 is C1-4 alkoxy, halo or trifluoromethyl； wherein R1 and R2 may alternatively form a 6-membered heteroaryl ring with n being 1 and R2 linked to X1； R3 is hydrogen or bromine； Ring A is selected from the group consisting of pyridine-N-oxide, benzo [1,3] dioxol-5-yl, 4,4-dimethylcyclohex-1-en-1-yl, indolyl, 1-methyl-indolyl, 2 , 3-dihydrobenzo [b] [1,4] -dioxin-6-yl, cyclopent-1-en-1-yl, benzofuranyl, phenyl and heteroaryl, wherein said heteroaryl, is a 5- to 6-membered ring which optionally contains 1 additional heteroatom selected from the group consisting of N, O and S； wherein said phenyl, and said heteroaryl is optionally substituted with R4； R4 is selected from the group consisting of hydroxyl, halo, cyano, amino, carboxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, di (C1-4 alkyl) amino, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl , C1-4 alkylcarbonylamino, di (C1-4 alkyl) amino-carbonyl, hydroxy-C1-4 alkyl, morpholin-4-yl-C1-4 alkoxy, imidazol-1-yl-C1-4 alkoxy, di (C1 alkyl - 4) C 1-4 amino-alkoxy, C 1-4 alkylsulfonyl, morpholin-4-yl-carbonyl, di (C 1-4 alkyl) aminoC 1-4 alkyl-aminocarbonyl, aminocarbonyl, 1-methyl-piperidin-4-yl -carbonyl, hydroxy-C1-4 alkyl-aminocarbonyl and C1-4-sulfinyl alkyl； and Q is selected from the group consisting of ** Formula ** or an enantiomer, diastereomer, solvate or pharmaceutically acceptable salt thereof.Un compuesto de Fórmula (I)**Fórmula** en el que X1, X2, X3 y X4 son independientemente CH o N； n es 0, 1 ó 2； R1 se selecciona del grupo consistente de alquilo C1-4, alcoxi C1-4, di(alquilo C1-4)amino, alquil-amino C1-4, amino, pirrolidin-1-il, nitro, halo, trifluorometoxi, trifluorometilo, y ciano； R2 es alcoxi C1-4, halo o triflu
