GELIN, Christine F.,LEBOLD, Terry P.,SHIREMAN, Brock T.,ZIFF, Jeannie M.
申请号：
LT14717576
公开号：
LT2970314T
申请日:
2014.03.12
申请国别(地区):
LT
年份:
2018
代理人:
摘要：
The present invention is directed to compounds of Formula I: wherein X is N or CR1； Y is N or CR2； R1 is H, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl； R2 is H, alkyl, alkoxy, or halo； Z is NH or O； R3 is H, alkyl, alkoxy, halo, or triazolyl； R4 is H or alkyl； or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5- or 6-membered heteroaryl ring； R5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl； and n is 1 or 2. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
