Alexander Richard Liam Cecil;Arasu Ganesan;Graham Keith Packham
发明人:
Arasu Ganesan,Graham Keith Packham,Alexander Richard Liam Cecil
申请号：
US12516110
公开号：
US08865655B2
申请日:
2007.11.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A compound of the general Structure (VII) or (VIII) including isoteres and pharmaceutically acceptable salts thereof, wherein R1, R2 (where X=—CONR6—), R3 and R7 are the same or different and each represents an amino-acid side chain moiety； R2 (where X=—CHZ—), R4 and R6 are the same or different and each represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl； K represents a linear or branched chain of carbon atoms and containing 1-10 atoms； L represents a moiety capable of chelating zinc in the active site of a histone deacetylase (HDAC) or of conversion to such a moiety in vivo (by hydrolysis or reduction, for example)； M is a linear or branched chain of carbon or other atoms and containing 1-10 atoms, and capable of undergoing in vivo cleavage to give Structure (VII)； and Z is a heteroatom bonded to the macrocycle by a single or double bond, and any other group bonded to Z is H or a protecting group.
