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POLYHETEROARL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY
专利权人:
Karus Therapeutics Limited
发明人:
Stephen Joseph Shuttleworth,Alexander Richard Liam Cecil,Somhairle MacCormick,William John Nodes,Cyrille Davy Tomassi,Franck Alexandre Silva
申请号:
US15522191
公开号:
US20170313698A1
申请日:
2015.10.29
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention is a compound having the following formula: or a pharmaceutically acceptable salt thereof, wherein e.g. L and Y are each independently an optionally substituted 6-membered nitrogen-containing heteroaryl; M is an optionallysubstituted 5- to 10-membered heteroaryl; W is a zinc-binding group; each R2 is independently hydrogen or C1-C6 alkyl; and R3 is an aryl or heteroaryl. The compounds are useful as histone deacetylase (HDAC) inhibitors.
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