Cecil, Alexander Richard Liam,Ganesan, Arasu,Packham, Graham Keith
申请号：
AU2007323215
公开号：
AU2007323215B2
申请日:
2007.11.22
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
A com ound of the eneral Structure (VII) or (VIII) including isoteres and pharmaceuticallyacceptable salts thereof, wherein R, R (where X = -CONR-),R and R are the same or different and each represents anamino-acid side chain moiety； R (where X = -CHZ-), R andR are the same or different and each represents hydrogen, C-Calkyl, C-C alkenyl, or C-C alkynyl；K represents a linear or branched chain of carbon atoms and containing 1-10 atoms；L represents a moiety capable of chelating zinc in the active site of a histonedeacetylase (HDAC) or of conversion to such a moiety in vivo (by hydrolysis orreduction, for example)； M is a linear or branched chain of carbon or other atomsand containing 1-10 atoms, and capable of undergoing cleavageto give Structure (VII)； and Z is a heteroatom bonded to the macrocycle by a singleor double bond, and any other group bonded to Z is H or a protecting group.
