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ВАРИАНТЫ ГРУППЫ 5 АЛЛЕРГЕНОВ ЗЛАКОВЫХ СО СНИЖЕННОЙ АЛЛЕРГЕННОСТЬЮ ВСЛЕДСТВИЕ МУТАГЕНЕЗА ОСТАТКОВ ПРОЛИНА
专利权人:
МЕРК ПАТЕНТ ГМБХ (DE)
发明人:
ВАЛЬД Мартин (DE),НАНДИ Андреас (DE),ФИБИГ Хельмут (DE),ВЕБЕР Бернхард (DE),КАЛЕРТ Хельга (DE),РЕЗЕ Геральд (DE),КРОМВЕЛЛЬ Оливер (DE)
申请号:
RU2012134508/10
公开号:
RU2012134508A
申请日:
2010.12.17
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Hypoallergenic option group 5 grass allergens family (Poaceae), in which prolines corresponding one alignment proline at position 57, 58, 117, 146, 155, 180, 211 in the amino acid sequence of wild type Phl p 5.0109 mutated singly or in combination .2. Hypoallergenic variant according to claim 1, characterized in that the proline corresponding one alignment proline 211 wild type Phl p 5.0109, is not deleted, and replaced by another aminokislotoy.3. Hypoallergenic variant of claim 1 or 2, wherein the prolines corresponding one alignment proline at position 146 and 155 in the amino acid sequence of wild type Phl p 5.0109, not mutirovany.4. Hypoallergenic variant of claim 1 or 2, wherein the additional amino acids corresponding to an alignment of the lysine at position 61 and glutamic acid at position 205 in the amino acid sequence of wild type Phl p 5.0109, mutated singly or in kombinatsii.5. Hypoallergenic variant of claim 1 or 2, characterized in that the group 5 allergens represents a group 5 allergens subfamily Pooideae.6. Hypoallergenic variant of claim 1 or 2, characterized in that the group 5 allergens selected from the group consisting of Phl p 5, Lol p 5, Poa p 5, Hol l 5, Dac g 5, Pha a 5, Ant about 5, Fes p 5, Hor v 5, Sec c 5, and Tri a 5.7. Hypoallergenic variant of claim 1 or 2, characterized in that it is a hypoallergenic variant of a fragment or variant of claim 1 or 2 or multimer of one or more of the hypoallergenic variants according to claim 1 or 2 or wherein the one or more embodiments hypoallergenic according to claim 1 or 2 or fragments, variants or multimers are recombinant sliyaniya.8 protein component. A DNA molecule encoding a hypoallergenic1. Гипоаллергенный вариант группы 5 аллергенов семейства злаковых (Poaceae), в которых пролины, соответствующие в одном выравнивании пролинам в положениях 57, 58, 117, 146, 155, 180, 211 в аминокислотной последовательности дикого типа Phl p 5.0109 мутировали отдельно или в комбинации.2. Гипоаллергенный в
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