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КОМБИНАЦИИ, ВКЛЮЧАЮЩИЕ САХАРИД ПНЕВМОКОККА СЕРОТИПА 14
专利权人:
НОВАРТИС АГ (CH)
发明人:
КОСТАНТИНО Паоло (IT)
申请号:
RU2014122163/15
公开号:
RU2014122163A
申请日:
2014.05.30
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An immunogenic composition comprising one or more polypeptides meningococcal and pneumococcal capsular saccharide serotypes 14, wherein (i) the capsular saccharide pneumococcal serotype 14 comprises tetrasaccharide Galβ1-4GlcNAcβ1-3Galβ1-4Glc, (ii) the meningococcal polypeptide may elicit an immune response effective against meningococcus serogroup B, and (iii) the composition does not contain meningokokka.2 lipooligosaccharides. Composition according to Claim. 1, wherein the polypeptide (s) comprise meningococcus (atm) fHBP.3. A composition according to claim. 2, where fHBP comprises the amino acid sequence identical by at least 85% SEQ ID NO: 1 and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 1.4. A composition according to claim. 2, where fHBP comprises the amino acid sequence identical by at least 85% SEQ ID NO: 2, and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 2.5. A composition according to claim. 2, where fHBP comprises the amino acid sequence identical by at least 85% SEQ ID NO: 3 and / or comprising an amino acid sequence consisting of a fragment of at least 7 consecutive amino acids from SEQ ID NO: 3.6. The composition according to claim. 2, 3, 4 or 5, wherein fHPB lipidirovan.7. The composition according to claim. 2, 3, 4 or 5, wherein fHBP induces antibodies that can bind to the meningococcal polypeptide consisting of the amino acid sequences of SEQ ID NO: 1, 2, or 3.8. The immunogenic without adjuvant composition comprising meningococcal lipooligosaccharides (LOS) and pneumococcal capsular saccharide serotype 14 (CS14), wherein as the LOS, and CS14 include tetrasaccharide Galβ1-4GlcNAcβ1-3Galβ1-4Glc.9. Immunogenic Compositions1. Иммуногенная композиция, содержащая один или более полипептидов менингококка и капсулярный сахарид пневмококка серотипа 14, где (i) капсулярный сахарид пневмококка серотипа 14 вкл
来源网站:
中国工程科技知识中心
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