ПИЦЦА Марияграция (IT),СКАРСЕЛЛИ Мария (IT),ДЖУЛИАНИ Марция Моника (IT),АРИКО Мария (IT),РАППУОЛИ Рино (IT)
申请号：
RU2012149618/10
公开号：
RU2012149618A
申请日:
2012.11.21
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A polypeptide comprising an amino acid sequence selected from the group consisting of the sequences SEQ ID NO: 20, 23, 76, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 , 17, 18, 19, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43 , 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68 , 69, 70, 71, 72, 73, 74 and 75.2. The polypeptide of claim 1 comprising the amino acid sequence of SEQ ID NO: 20.3. The polypeptide of claim 2 comprising a sequence SEQ ID NO: 79.4. The polypeptide of claim 1 comprising the amino acid sequence of SEQ ID NO: 23.5. The polypeptide of claim 4 comprising the sequence of SEQ ID NO: 80.6. The polypeptide of claim 1 comprising the amino acid sequence of SEQ ID NO: 76.7. The polypeptide of claim 6 comprising the sequence of SEQ ID NO: 77.8. A polypeptide comprising the amino acid sequence (i) which has at least 90% identity with the sequence SEQ ID NO: 76 and / or (ii) comprises a first fragment and a second fragment of the sequence SEQ ID NO: 76, wherein said first fragment includes an epitope located within the amino acid sequence 89-154 SEQ ID NO: 76, and said second fragment includes an epitope located within amino acids 187-248 sequence of SEQ ID NO: 76.9. Nucleic acid encoding a polypeptide according to any one of the preceding punktov.10. A plasmid containing a nucleotide sequence encoding a polypeptide according to any one pp.1-8.11. A host cell transformed with a plasmid of p.10.12. The host cell of claim 11, wherein the cell is a meningococcal bakteriey.13. Membrane vesicles prepared from the host cell of claim 12, wherein the vesicles include a polypeptide according to any one pp.1-8.14. An immunogenic composition comprising a polypeptide according to any one of claims 1-8 or of a vesicle p.13.15. com1. Полипептид, содержащий аминокислотную последовательность, выбранную из группы, состоящей из последовательностей SEQ ID NO: 20, 23, 76, 4, 5, 6, 7
