The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I)useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.本發明有關式(I)之6-經取代異喹啉及異喹啉酮衍生物其可用以治療及/或預防與Rho-激醯及/或由Rho-激酶介導之肌球蛋白輕鏈磷酸酶磷酸化有關的疾病;及含有該等化合物之組成物。