The present invention is to provide a kind of these salt by being licensed in formula (1) compound represented, its forerunner's drug or pharmacy and the effective treatment of the proliferative diseases to cancer etc. containing the compound and prevent useful medicine, medical component etc..The series of compounds is by formula (1):(in formula, X expression can substituted aryl or heteroaryl； Cy indicates 4 ~ 7 Yuans monocyclic heterocycles or 8 ~ 10 Yuans condensation heterocycles that can be substituted； Z indicate O, S or NRa) represented by person.本發明為提供一種由式(1)所示的化合物、其前驅藥物、或製藥上被許可的這些鹽、以及含有該化合物之對癌等之增殖性疾病有效之治療及預防有用的醫藥、醫藥組成物等。該化合物係由式(1)：〔式中，X表示可被取代的芳基或雜芳基；Cy表示可被取代之4~7員單環雜環或8~10員縮合雜環；Z表示O、S或NRa〕所表示者。
