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antitumor compounds
专利权人:
PHARMA MAR S.A.
发明人:
RODRIGUEZ VICENTE, ALBERTO,GARRANZO GARCIA-IBARROLA, MARIA,MURCIA PEREZ, CARMEN,SANCHEZ SANCHO, FRANCISCO,CUEVAS MARCHANTE, MARIA DEL CARMEN,MATEO URBANO, CRISTINA,DIGON JUAREZ, ISABEL
申请号:
ES08865009
公开号:
ES2384420T3
申请日:
2008.12.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of general formula I in which Y is selected from -CHRay-, -CHRay-CHRby-, -CRay>; = CRby-, -C≡C-, -CHRay-CHRby-CHRcy-, -CHRay-CRby>; = CRcy - and -CHRay-C≡C-; each Ray, Rby, and Rcy is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; each R1, R2, R3, R4, and R5 is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; R6 is selected from NR8R9, and OR10; W is selected from O and NR7; R7 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl, or R7 and R5 together with the corresponding N atom and the C atom to which they are attached can form a substituted or non-substituted heterocyclic group substituted; R8 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenyl; R10 is selected from hydrogen, substituted C2-C12 alkenyl or unsubstituted, and substituted or substituted C2-C12 alkynyl; each dotted line represents an optional additional bond provided that one or more additional links are present, but when there is a triple bond between the C atoms to which they are attached R1 and R2, R1 and R2 are absent, and when there is a triple bond between the C atoms to which R3 and R4 are attached, R3 and R4 are absent; R9 is selected from hydrogen, CORa, COORa, substituted C2-C12 alkenyl or unsubstituted, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkeninyl; each group R11, R12, R13, R14, and R15 is independently selected from hydrogen, halogen, ORa, CORa, COORa, OCORa, OCO ORa, OCONRaRb, CONRaRb, OS (O) Ra, OSO2Ra, OP (O) (Ra) ORb, OSiRaRb
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