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antitumor compounds
专利权人:
PHARMA MAR S.A.
发明人:
RODRIGUEZ VICENTE, ALBERTO,GARRANZO GARCIA-IBARROLA, MARIA,MURCIA PEREZ, CARMEN,SANCHEZ SANCHO, FRANCISCO,CUEVAS MARCHANTE, MARIA DEL CARMEN,MATEO URBANO, CRISTINA,DIGON JUAREZ, ISABEL
申请号:
ES08864895
公开号:
ES2442140T3
申请日:
2008.12.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of general formula I ** Formula ** in which Y is selected from -CHRay-, -CHRay-CHRby-, -CRay>; = CRby-, -CC-, -CHRay-CHRby-CHRcy-, -CHRay- CRby>; = CRcy- and -CHRay-CC-; each Ray, Rby and Rcy are independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl and substituted or unsubstituted C2-C12 alkynyl; each R1, R2, R3, R4 and R5 are independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl and substituted or unsubstituted C2-C12 alkynyl; R6 is selected from NR8R9 and OR10 ;; A is ** Formula ** W is selected from O and NR7; R7 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl and substituted or unsubstituted C2-C12 alkynyl, or R7 and R5 together with the atom of N and C-atom corresponding to which they are attached can form a substituted or substituted heterocyclic group; R8 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or substituted C4-C12 alkenyl; R10 is selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl and substituted or unsubstituted C2-C12 alkynyl; each dotted line represents an optional bond, but when there is a triple bond between the atoms of C to which R1 and R2 are attached, R1 and R2 are absent, and when there is a triple bond between the atoms of C to which R3 are attached and R4, R3 and R4 are absent; R9 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or substituted C4-C12 alkenyl, with the proviso that when And it is - CHRay-CHRby-CHRcy- or -CHRay-CRby>; = CRcy- and there is a single or double bond
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