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Chromane substituted compounds as modulators of Calcium Sensing Receptors
专利权人:
LUPIN LTD.
发明人:
申请号:
ARP130100556
公开号:
AR090135A1
申请日:
2013.02.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Claim 1: a compound of formula (1) screened between hydrogen, halogen, substituted or unsubstituted tar, cyanogen, unsubstituted cyclopentyl and substituted or unsubstituted halogens; r74959;In each case, it may be the same or different, with independent selection between hydrogen, halogen, substituted or unsubstituted tar, substituted or unsubstituted cyclopentyl compound and substituted or unsubstituted halogenated compound; in each case, it may be the same or different, with independent selection between halogen and hydrogen Xi, Substituted or unsubstituted tar, substituted or unsubstituted bittern tar, substituted or unsubstituted calcium, substituted or unsubstituted asphalt, substituted or unsubstituted cyclopentyl compound, or 8310;nitro ciano -C (O) OR- (CH) -C (O) OR-OC (O) OR-O (CH) -C (O) OR-8311; 831222;- (CH) NR R-C (O) R-C (o) No. 8311; (r83212);- (CH) -C (O) NR R-No. 8311; (C (o) r8313,-S (O) R-S (O) NR Ry -NR S (O) RX selected from a link, - (CR 7580; r749696) 691;- that is...-No. 8311,-No. 831111 (cr7580r7496691 -;-O (CR R) --C (o) 8311 -,-C (o) No. 8311a (cr.7580); r749661 -;- (CR R) NR (CR R) --(cr.7580; r74966) 691-cyclopropyl lino, cyclopropyl lino, cyclopropyl lino (cr.7580; r74966) 691-y-o-cyclopropyl lino, in which cyclopropyl lino can be replaced or not; r75808 and r74966;In each case, they may be the same or different, respectively, selected from hydrogen, halogen, hydrogen Xi, cyanogen, nitrogen, alternative or unsubstituted asphalt, alternative or unsubstituted halogen tar and alternative or unsubstituted cyclopentyl gas; or r75808 and r74966;When combined with carbon atoms, they can form a saturated or unreplaced carbon ring, which is composed of 3 to 7 members;R1,May be the same or different in each case, selected from halogen, nitrogen, cyanogen, alternative or unsubstituted asphalt, alternative or unsubstituted asphalt, alternative or unsubstituted halide, alternative or unsubstituted cyclopropyl compound, alternative or unsubstituted
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