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Heterocyclic derivatives as modulators of TRPV3
专利权人:
ABBVIE INC.
发明人:
BRUCE CLAPHAM,PHIL B. COX,JEROME F. DAANEN,ARTHUR GOMTSYAN,MICHAEL E. KORT,PHILIP R KYM,ERIC A. VOIGHT,ROBERT G. SCHMIDT,MICHAEL J. DART,GREGORY GFESSER,EROL K. BAYBURT
申请号:
ARP120103976
公开号:
AR088511A1
申请日:
2012.10.24
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
In addition, it includes the components of these compounds and the methods of using them to deal with conditions and disorders. Claim 1: a compound characterized as formula (1) or salt, wherein r74919 and r74955 are independent between hydrogen, asphalt, halogen, halogen, Oh or (asphalt);O a phenyl group selectively substituted by 1, 2, 3, 4 or 5 substitutes independently selected from asphalt, halogen and halogen groups; u is 0, 1 or 2; X3 is O; x8308es is O, x8309es (ch83222) - 8345;N is 2; o x 3 is O; x8308es (ch.83222);X es (CH)m and n are each 1; or X³ is O; X⁴ is (CH₂) ₘ,X es (CH)M is 1, n is 2; or X3 is O; x83088 is a combination, x8309es (ch832245);N is 3; X1 is hydrogen; G is arilo, heteromorphic, cyclopropyl, heterocyclic, or cyclopropene; each of them can be replaced by 1, 2, 3, 4, or 5 substitutes independently selected from the group consisting of asphalt, alquenilo, asphalt, halogen, halogen, or750175;N (R)N (r7501;; 758080) C (o) tar, isomerization and heterocycle; the units of isomerization and isomerization are not replaced or replaced by 1, 2, 3, 4 or 5 substitutes selected from asphalt or (asphalt) group,hal geno y haloalquilo y donde cada R es en forma independiente hidr geno alquilo o haloalquilo G es G o - (CR R) -G donde r es 1 2 3 R y R son iguales o diferentes y son en forma independiente entre s hidr geno N (R)C (O) alkyl, or haloalkyl; where each R¹ᵍᶜ is independently hydrogen, alkyl, or haloalkyl; G²ᵈ is aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of Gᵈ,Tar, amino, tar, halogen, halogen,-OC (O) R-OC (O) N (R)-S (O) R-S (O) N (R)-C (O) R-C (O) OR-C (O) N (R)-N (R)-N (R) C (O) R-N (R) S (O) R-N (R) C (O) O (R)-N (R) C (O) N (R)- (CR R) q-G- (CR R) q-OR- (CR R) q-OC (O) R- (CR R) q-OC (O) N (R)- (CR R) q-S (O) R- (CR R) q-S (O) N (R)- (CR R) q-C (O) R- (CR R) q-C (O) OR- (CR R) q-C (O) N (R)- (CR R) q-N
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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