APE1 / REF-1 PURPOSE METHODS FOR INHIBITING THE TRANSDUCTION GENES OF HYPOXIA SIGNALS

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专利权人:

ИНДИАНА ЮНИВЕРСИТИ РИСЕРЧ ЭНД ТЕКНОЛОДЖИ КОРПОРЕЙШН (US)

发明人:

КЕЛЛИ, Марк Р. (US),ФИШЕЛ, Мелисса (US)

申请号：

RU2017144823

公开号：

RU2017144823A

申请日:

2016.05.05

申请国别(地区):

RU

年份:

2019

代理人:

摘要：

Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.

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