INDIANA UNIVERSITY RESEARCH and TECHNOLOGY CORPORATION
发明人:
KELLEY, Mark R.,FISHEL, Melissa
申请号：
PH12017502121
公开号：
PH12017502121A1
申请日:
2017.11.21
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APEl/Ref-1) are disclosed. More particularly, methods for inhibiting APEl/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.
