INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION
发明人:
KELLEY, MARK R.,FISHEL, MELISSA
申请号：
CA2986248
公开号：
CA2986248A1
申请日:
2016.05.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APEl/Ref-1) are disclosed. More particularly, methods for inhibiting APEl/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.
