Mark R. KELLEY;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;Melissa FISHEL
发明人:
Mark R. KELLEY,Melissa FISHEL
申请号：
IL25561117
公开号：
IL255611D0
申请日:
2017.11.12
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.
